rtPA recombinant tissue plasminogen activation
rtPA tPA can be manufactured using recombinant biotechnology techniques; tPA produced by such means are referred to as recombinant tissue plasminogen activator ( rtPA ). Specific rtPAs include alteplase , reteplase , and tenecteplase . They are used in clinical medicine to treat embolic or thrombotic stroke . The use of this protein is contraindicated in hemorrhagic stroke and head trauma. The antidote for tPA in case of toxicity is aminocaproic acid . Caranya: 100 mgr terbagi dalam 1. 50 mgr bolus IV 2. 20 mgr bolus IV pada jam ke-2 3. 30 mgr bolus IV pada jam ke-3 atau alternatif 1. 60 mgr bolus IV 2. 20 mgr bolus IV 3. 20 mgr bolus IV https://www.researchgate.net/publication/8358453_The_Neurotoxicity_of_Tissue_Plasminogen_Activator/figures?lo=1 http://americanhistory.si.edu/collections/search/object/nmah_1000953